A comprehensive study was conducted to evaluate the impact of liquid and lime additives on the performance of asphalt pavements from five different sources around the United States. Three types of mixtures were evaluated from each source: un-treated, liquid-treated, and lime-treated. The measured properties of the fifteen mixtures included the dynamic modulus master curves and their resistance to rutting and fatigue at the undamaged and moisture damaged conditions. The measured performance properties of the mixtures were used in the AASHTO MechanisticEmpirical Pavement Design Guide (MEPDG) to conduct 20 years structural designs for actual projects selected from the five sources of mixtures. For each project, a total of three structural designs were established by changing the type of mix used in the asphalt layer e.g. un-treated, liquid-treated, and lime-treated. The MEPDG structural designs were used with typical cost figures for the three types of mixtures to estimate the costs of the three types of structural designs for each project. The percent cost savings/additional costs were estimated relative to the cost of the asphalt pavement with the un-treated asphalt mixtures. Overall, the use of lime additives in asphalt mixtures resulted consistently in significant savings that sometime was as high as 45%. On the other hand, the use of liquid anti-strip additives in asphalt mixtures may either result in savings between 13 and 32% or an additional cost, in some cases as high as 50%. The additional cost for the liquid-treated mixes was observed for mixtures that were not considered moisture sensitive as measured by AASHTO T283.