The common practice for designing asphalt pavement structures in Quebec has been based on the AASHTO 93 method for over twenty years. This approach was developed to determine the components of a pavement structure to ensure, from a structural standpoint, adequate performance throughout the pavement’s expected life. Validating and calibrating a mechanistic-empirical (ME) method would notably allow better consideration of Quebec’s specific climatic conditions. In the current practice in Quebec, the structural design method is limited to dividing the province into two climatic zones (South and North). In contrast, the ME method proposed by the AASHTO simulates the effects of hourly temperature distribution, precipitation, sunlight, wind speed, and even the depth of the water table. The ME approac haims to establish links between the characteristics of pavement materials, climatic conditions, and traffic loading to predict the occurrence and progression of various degradation mechanisms. Before implementing this pavement design method, it is essential to calibrate the prediction models to Quebec’s conditions to reduce biased measurements that often reflect inadequate correlations between field results and predictions. This study will undertake a local calibration for flexible pavements in Quebec using AASHTOWare Pavement Mechanistic-Empirical Design (PMED) to ensure accurate predictions under local conditions. The Calibration Assistance Tool (CAT) of the AASHTOware Pavement ME Design has been used to assess the local calibration factors for the performance models, including Bottom-Up Fatigue Cracking, Total Rutting, Transverse Cracking, and International Roughness Index (IRI). A total of 353 flexible pavements under the authority of the Ministère des Transports et de la Mobilité Durable (MTMD) have been retained concerning several criteria. Better accuracy of pavement performance has been yielded based on the goodness of fit between local and national calibration findings. Results show enhanced predictions in the case of Fatigue cracking, Rutting and International Roughness Index compared to the global calibration.